Panitumumab

What is Panitumumab for?

Panitumumab is a targeted medication used to treat colorectal cancer. It works by binding to a protein called epidermal growth factor receptor (EGFR) on cancer cells, blocking the cancer cells’ ability to grow. It may be given on its own or in combination with other chemotherapy drugs.

How should I take or use Panitumumab?

Panitumumab is injected into the vein (given intravenously) as an infusion (drip).

What precautions should I take when taking or using Panitumumab?

Inform your healthcare professional if:

• You are allergic to this medication or any of the other ingredients of this medication.
• You are pregnant, planning to become pregnant, or breastfeeding.
  • Female patients who may become pregnant should use effective birth control during treatment and for 2 months after their last treatment.
  • Do not breastfeed during treatment and for 2 months after your last dose.
• You are taking any other medications, including supplements, traditional medications and herbal remedies.

What food or medication should I avoid when I take or use Panitumumab?

Avoid taking traditional Chinese medications (TCM) or “jamu” when you are on this medication.

What are some common side effects of Panitumumab?

• Skin rashes that look like acne (pimples), usually occurring over the face, chest and back. Rash may also be itchy.
  • Protect yourself from the sun by using sunscreen, wearing long-sleeved clothes and long pants, and avoid spending time directly under the sun.
  • Use moisturizer regularly to prevent dry skin.
• Nail changes, increased risk of nail infections. This may appear as redness, swelling or tenderness around the nail bed.
  • Keep nails short and avoid prolonged contact with water and harsh detergents.
• Changes to hair texture
  • May also affect facial hair and eyelashes.
• Mouth ulcers
  • Avoid eating hard or spicy foods.
  • Brush teeth with a soft-bristled toothbrush.
  • Use a non-alcohol-containing mouthwash to maintain mouth hygiene after meals.
• Diarrhea or constipation
  • To manage diarrhea:
    • Drink more water or clear fluids to replace the fluids lost.
    • Avoid oily, spicy food or dairy products.
  • To manage constipation:
    • Drink more water or clear fluids (if you do not have a limit on the amount of water you can drink each day).
• Low magnesium levels (a type of mineral needed by the body). Some people may have symptoms such as muscle cramps, weakness, numbness and tingling, while some people may not experience any symptoms at all.

What are some rare but serious side effects that I need to seek medical advice immediately?

• Infusion reaction, which is an allergic reaction that happens during the infusion. Symptoms include one or more of the following:
  • Fever, chills or shivering
  • Difficulty breathing
  • Feeling dizzy or lightheaded
  • Itchy rashes
  • Swollen face/eyes/lips/tongue
• Symptoms of lung problems such as a dry cough that doesn’t go away and feeling breathless
• Severe skin rashes affecting a large area of the body or causing pain and blistering
• Severe diarrhea (more than 4 times a day)
• Symptoms of eye problems such as sudden or worsening eye pain, eye redness, teary eyes, light sensitivity or blurring of vision

If you experience any of these symptoms, you should see your healthcare professional immediately.