Denosumab

What is Denosumab for?

Denosumab is a medication given to reduce bone breakdown, thus lowering the risk of broken bones or cancer-related bone pain.

It is available in two brands, with different uses. Do not use the two brands interchangeably unless otherwise instructed by your doctor.

Xgeva® is used to treat giant cell tumor of bone or  conditions where cancer has spread to the bone.

Prolia® is used to treat or prevent osteoporosis.

How should I take or use Denosumab?

Denosumab is an injection given under the skin (subcutaneously) at the upper arm, upper thigh or abdomen.

The interval between each injection you receive depends on what you are being treated for. Your doctor will inform you accordingly.

Do not shake the vial or syringe vigorously.

What should I do if I forget to take or use Denosumab?

If you miss a dose, receive it as soon as possible by rescheduling an administration date with your clinic.

What precautions should I take when taking or using Denosumab?

• Ensure you are taking enough calcium and vitamin D daily, unless otherwise instructed by your doctor.
• Maintain good oral hygiene. Inform your dentist that you are on Denosumab.
• For women: Use effective birth control and inform your doctor if you intend to get pregnant or breast-feed. 

What are some common side effects of Denosumab?

• Muscle, back, bone or joint pain
• Nausea or vomiting
• Constipation or diarrhea
• Slight tiredness
• Increased cholesterol levels

• Inform your doctor if any of the following occurs:
• Excessive muscle cramping
• Giddiness or confusion
• Excessive skin dryness, irritation or rashes
• Chest pain or shortness of breath
• Fever, pain upon urination, gum pain or gum bleeding
• Severe nausea or vomiting or abdominal pain
• Allergic reaction e.g. rash, swelling of eyelids and face

How should I store Denosumab?

• Keep away from children
• Keep in a cool, dry place, away from direct sunlight
• Store in the refrigerator. Do not freeze.