Dr Jonathan Fang

Dr Jonathan Xinguo Fang is an Associate Consultant from the Department of Cardiology at National Heart Centre Singapore. He obtained his medical degree and completed residency and fellowship in cardiology at the University of Hong Kong and its main teaching hospital, Queen Mary Hospital, Hong Kong. He further completed two prestigious fellowships in the United States, including an interventional cardiology fellowship at Brigham & Women’s Hospital, Harvard Medical School, Massachusetts (2022-2023), and a structural heart disease fellowship at Henry Ford Health System, Michigan (2023-2024). His clinical interests include innovative techniques and education in interventional cardiology.

• Structural Heart Disease fellowship. Henry Ford Health System, USA, 2023 - 2024
• MPH Candidate. Harvard School of Public Health, Harvard University, 2024 - Present
• Interventional Cardiology Fellowship. Brigham and Women’s hospital, Harvard Medical School, 2022 - 2023
• Global Clinical Scholar Research Training. Harvard Medical School, 2018 - 2019
• FHKAM (medicine), Hong Kong, 2019
• MRCP Royal College of Physicians, United Kingdom, 2014
• MBBS University of Hong Kong, 2011

• Associate Consultant, Department of Cardiology, National Heart Centre Singapore, 2024 - Present
• Clinical Instructor, Duke-NUS Medical School
• JSCAI Editorial fellow, Society for Cardiovascular Angiography & Interventions (SCAI), 2025 - Present
• Fellow, American College of Cardiology
• Fellow, Society for Cardiovascular Angiography & Interventions
• Fellow, Hong Kong College of Physicians
• Fellow, Hong Kong Academy of Medicine
• Member, Singapore Cardiac Society
• Member, Hong Kong College of Cardiology
• Member, Royal College of Physicians, UK
• Faculty / Scientific committee: TCT, CRT, TCTAP, APCASH, Singapore LIVE, among others.

• Early Career Leader Scholarship. Cardiovascular Research Technologies (CRT), 2025
• Best of JACC. For the article titled “LAVA-ECMO-supported Dual-Transcatheter Aortic and Mitral Valve-in-Valve Replacement in Cardiogenic Shock”, published in JACC-case reports and reprinted in JACC, April 29, 2025
• Reviewer of the month, Cardiovascular Diagnosis & Therapy, 2025
• Best interventional case: TCTAP 2025; TCTAP 2023; APCASH 2024, APCASH 2023 (runner-up); Hong Kong Heart Foundation PCI competition 2019, among others
• Top 10 Interventional case. Cardiovascular Research Foundation, TCT, 2024
• Best Abstract. APCASH 2024; CSI-Asia 2024 (1st runner-up); Medical Research Conference 2019
• Hong Kong Heart Foundation Fellowship, 2020
• Outstanding staff and Teams Award, Hong Kong Hospital Authority, 2019
• Distinction, University of Hong Kong MBBS curriculum, 2011

• Innovative techniques in interventional cardiology
• Minimalism and alternative access in interventional cardiology
• User dependence and technique reproducibility in interventional cardiology

(As co-investigator)

• PEERLESS (Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism)
• ONYX ONE (Polymer-based or Polymer-free Stents in Patients at High Bleeding Risk)

• Fang, J. X., O’Neill, B. P., et al. (2025). Transjugular approach for Evoque transcatheter tricuspid valve replacement in patients with challenging anatomy. Circulation: Cardiovascular Interventions. (Accepted) 
• Fang, J. X., Chan, Y. H., Almarzooq, Z. I., Lam, C. C. S., Wong, Y. T. A., Tun, H. N., et al. (2025). Effectiveness of a simplified checklist to overcome the inertia of treatment implementation in ACS patients with high comorbidity burden. Journal of Clinical Medicine, 14(7), 2469. 
• Fang, J. X., Engel Gonzalez, P., Villablanca, P. A., et al. (2025, January 2). Flaring of protruding coronary stents before transcatheter aortic valve replacement to minimize interaction: A feasibility study. Catheterization and Cardiovascular Interventions. 
• Fang, J. X., O'Neill, B. P., Wang, D. D., et al. (2024). Feasibility and technicality of aortic valve lithotripsy-facilitated balloon valvuloplasty in patients with severe aortic stenosis unsuitable for immediate valvular replacement. Cardiovascular Revascularization Medicine. 
• Fang, J. X., Giustino, G., Lee, J., et al. (2024). Direct electrosurgical traversal with radiofrequency to prevent obstruction in left ventricular outflow tract (DETROIT). JACC: Cardiovascular Interventions, 0(0). 
• Fang, J. X., Villablanca, P. A., et al. (2024). Fish and CHIP: Concurrent percutaneous left-ventricular thrombus retrieval and complex coronary intervention with hemodynamic support. JACC: Cardiovascular Interventions, 0(0). 
• Giustino, G., Fang, J. X., Frisoli, T. M., Lee, J. C., Nguyen, F., Engel, P., et al. (2024). Early outcomes of transjugular transcatheter tricuspid valve replacement. JACC: Cardiovascular Interventions, 0(0). 
• Giustino, G., Fang, J. X., Villablanca, P. A., Wang, D. D., Sturla, N., Lee, J. C., et al. (2024). Intravascular lithotripsy-facilitated balloon valvuloplasty for severely calcified mitral valve stenosis. JACC: Cardiovascular Interventions, 17(2), 326–327. 
• Giustino, G., O'Neill, B. P., Wang, D. D., Frisoli, T. M., Fang, J. X., Engel Gonzalez, P., et al. (2024). Feasibility and safety of transcaval venoarterial extracorporeal membrane oxygenation in severe cardiogenic shock. EuroIntervention, 20(8), e511–e513. 
• Fang, J. X., Giustino, G., Apostolou, D., Lee, J. C., Wang, D. D., Gonzalez, P. E., et al. (2024). LAVA-ECMO–supported dual-transcatheter aortic and mitral valve-in-valve replacement in cardiogenic shock. JACC: Case Reports, 29(19), 102564. 
• Fang, J. X., Giustino, G., Frisoli, T. M., Lee, J. C., & Villablanca, P. A. (2025). Lacerate and macerate: The BASILICA–LLAMACORN/UNICORN combination to optimize bioprosthetic bileaflet modification. Journal of the Society for Cardiovascular Angiography & Interventions. 
• Fang, J. X., Giustino, G., Villablanca, P. A., O’Neill, B. P., Alrayes, H., Selektor, Y., et al. (2024). The challenge of transcatheter aortic valve replacement in quadricuspid aortic valve with pure insufficiency. JACC: Cardiovascular Interventions, 0(0). 
• Fang, J. X., Villablanca, P. A., O’Neill, B. P., et al. (2024). Mechanical circulatory support–assisted percutaneous rescue of ventricularly embolized transcatheter heart valve. JACC: Cardiovascular Interventions, 0(0). 
• Fang, J. X., Wang, D. D., Giustino, G., et al. (2024). Minimalistic transcaval TAVR for a patient with a small aorta. JACC: Cardiovascular Interventions, 17(8), 1047–1049 
• Fang, J. X., Frisoli, T., Lee, J. C., et al. (2024). ECG-gated CT improves diagnosis in prosthetic valve degeneration. European Heart Journal – Imaging Methods and Practice. 
• Fang, J. X., Fram, G., Engel Gonzalez, P., et al. (2024). Subaortic membrane and cardiac catheterization—beware of diagnostic pitfall. Journal of the Society for Cardiovascular Angiography & Interventions. 
• Giustino, G., Lee, J. C., O’Neill, B. P., Fang, J. X., Zweig, B., Jabri, A., et al. (2025). Single-access technique for Impella-assisted balloon aortic valvuloplasty and high-risk PCI in cardiogenic shock. JACC: Case Reports, 30(5), 102986. 
• Fang, J. X., O’Neill, B. P., Frisoli, T. M., Lee, J. C., Giustino, G., Engel Gonzalez, P., O’Neill, W. W., & Villablanca, P. A. (2025). Aortic valve stenosis and calcified abdominal aortic stenosis treated with lithotripsy-facilitated TAVR and aortic stenting. JACC: Case Reports. (In press) 
• Fang, J. X., Villablanca, P. A., et al. (2025). Do not BASILICA the new valve. JACC: Case Reports, 0(0). In press. 
• Fang, J. X., O’Neill, B., Frisoli, T., et al. (2024). Stuff and plug: The combination use of coils and nitinol occluder for intracardiac cul-de-sacs. JACC: Cardiovascular Interventions, 17(13), 1615–1618. 
• Giustino, G., O'Neill, B. P., Wang, D. D., Fang, J. X., Frisoli, T. M., Lee, J. C., et al. (2024). Redo transcaval access and closure for redo transcatheter aortic valve replacement. JACC: Cardiovascular Interventions, 17(8), 1053–1056. 
• Gupta, K., Villablanca, P., Gonzalez, P. E., O’Neill, B., O’Neill, W. W., Wang, D. D., Fang, J. X., et al. (2024). Association of relative left ventricular outflow tract area and transcatheter aortic valve replacement related paravalvular leak. Journal of the Society for Cardiovascular Angiography & Interventions, 3(3PtB), 101294. 
• Tam, C. C. F., Cheung, K. S., Lam, S., Wong, A., Yung, A., Sze, M., Fang, J. X., Tse, H. F., & Siu, C. W. (2021). Impact of coronavirus disease 2019 (COVID-19) outbreak on outcome of myocardial infarction in Hong Kong, China. Catheterization and Cardiovascular Interventions, 97. 
• Hai, J. J., Mao, Y., Zhen, Z., Fang, J. X., Wong, C. K., Siu, C. W., Yiu, K. H., Lau, C. P., & Tse, H. F. (2021). Close proximity of leadless pacemaker to tricuspid annulus predicts worse tricuspid regurgitation following septal implantation. Circulation: Arrhythmia and Electrophysiology, 14(5). 
• Ren, Q. W., Li, X. L., Fang, J. X., et al. (2020). The prevalence, predictors, and prognosis of tricuspid regurgitation in stage B and C heart failure with preserved ejection fraction. ESC Heart Failure, 7(6), 4051–4060. 
• Hai, J. J., Fang, J. X., Tam, C. C. F., Wong, C. K., Un, K. C., Siu, C. W., Lau, C. P., & Tse, H. F. (2019). Safety and feasibility of a midseptal implantation technique of a leadless pacemaker. Heart Rhythm, 16(6), 896–902. 
• Fang, J. X., Almarzooq, Z. I. (2022). Elevated lipoprotein (a) levels in East Asia: Bridging the ethnicity data gap. European Journal of Preventive Cardiology, 30(4), 305–307. 
• Fang, J. X., Yung, A. S., Lam, S. C., & Tam, F. C. (2022). Coronary intravascular lithotripsy in a tight circumferential calcified lesion in the presence of haematoma extending into left main coronary artery after rotational atherectomy. Interventional Cardiology, 17. 
• Fang, J. X., et al. (2017). Extrinsic pulmonary artery compression mimicking acute pulmonary embolism. Clinical Case Reports, 5(10), 1591–1593.