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Dr Loh Wann Jia

Dr Loh Wann Jia

BSc (Endocrinology), MBBS, MRCP, MMed, MCI (Singapore)

Senior Consultant

Changi General Hospital

Specialty: Endocrinology

Conditions Treated by this Doctor:
Diabetes Mellitus , General Endocrinology , Lipid disorders , Obesity .

Clinical Appointments

  • Senior Consultant Endocrinology Changi General HospitalChangi General Hospital
  • Co-Lead, Specialist (Diabetes) Care SingHealth Duke-NUS Diabetes Centre

Academic Appointments

  • Clinical Assistant Professor, Duke-NUS Medical School
  • Clinical Lecturer, NUS Yong Loo Lin School of Medicine
  • Physician Faculty Member, SingHealth Endocrinology Residency Programme

Profile

Dr Loh Wann Jia is a Senior Consultant with the Department of Endocrinology at Changi General Hospital (CGH). She also specialises in Internal Medicine, with clinical interests in metabolic conditions, including dyslipidaemia, obesity, diabetes, and insulin resistance. Dr Loh obtained her Bachelor’s in Endocrinology from the Imperial College London in 2011 and went on to complete her Master of Medicine. Subsequently, she embarked on two overseas clinical fellowships with research components: one at the Imperial College London in 2017 and another at the Royal Perth Hospital in 2022. Dr Loh set up the Lipid clinic and service in Changi General Hospital.

Dr Loh’s primary research interests are in metabolic conditions including hyperlipidaemia, obesity, diabetes, and insulin resistance. As a primary investigator and co-investigator of multiples studies, Dr Loh has been awarded multiple research grants, with the aim of translating key research findings into clinical practice for improved patient care. Her dedication to medical research has been recognised at various research awards, such as the National Medical Research Council (NMRC) Research Training Fund, NMRC Population Health New Investigator Grant, and Nurturing Clinician Researcher Award by the SingHealth Duke-NUS Medicine Academic Clinical Programme (ACP). In 2022, she was conferred the SingHealth Publish! Award for her paper titled “Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population”, published in European Atherosclerosis Society journal, Atherosclerosis.

Education

  • MCI, Singapore, 2021
  • MRCP(UK), 2011
  • MMed, Singapore, 2011
  • MBBS, UK, 2008
  • BSc, UK, 2008

Professional Appointments and Committee Memberships

  • Member, Obesity Multidisciplinary Team, Changi General Hospital, 2016 – Present
  • Core Faculty, Post-Graduate Year 1 (PGY1), 2020 – 2021
  • Secretary, Singapore Association of Obesity (SASO), 2019 – 2021

Awards

  • Grand Winner, Research, Innovation and Enterprise (RIE) Day, Changi General Hospital, 2024
  • Star Award, Singapore Quality Service Awards, 2023
  • Publish! Award, SingHealth, 2022 
  • Nurturing Clinician Researcher Scheme (NCRS) Award, SingHealth Duke-NUS Medicine ACP, 2022
  • Gold Award, Singapore Health Quality Service Awards, 2022
  • Health Manpower Development Plan (HMDP) Award, Ministry of Health, 2022
  • Special Recognition Award, NUS Yong Loo Lin School of Medicine, 2021 
  • Senior Educator Award, SingHealth Duke-NUS Medicine ACP Education Awards, 2021
  • Outstanding Faculty Award, Residency in SingHealth Excels (RiSE), 2020 
  • Silver Award, Singapore Health Quality Service Awards, 2020
  • Outstanding Faculty Award, Residency in SingHealth Excels (RiSE), 2018
  • Outstanding Faculty Award, Residency in SingHealth Excels (RiSE), 2017
  • Silver Award, Singapore Health Quality Service Awards, 2017

Research Interests

  • Lipid disorder
  • Obesity
  • Diabetes
  • Metabolism

Publications

  • Wann Jia Loh. Overview of diabetes agents in cardiovascular disease: it takes an orchestra to play Tchaikovsky in symphony. Current Opinion in Endocrinology & Diabetes and Obesity. Nov 2024. PMID
  • Clara Tan, Wann Jia Loh, Su Chi Lim. Precision medicine in diabetes care. Current Opinion in Endocrinology & Diabetes and Obesity. Nov 21 2024. PMID 39564663
  • Colin Yeo, Xuan Han Koh, Weien Chow, Lily Mae Dacay, Aw Tar Choon, Wann Jia Loh. Lipoprotein(a) may be falsely lowered when troponin T is elevated in patients with ischaemic heart disease during acute admission. Journal of Asian Pacific Society of Cardiology, accepted 5 Nov 2024
  • Ying Hui Mak, Fionn Chua, Xuan Han Loh, Vern Hsen Tan, Zhong Hui Lee, Audrey Lam, Kim Leng Tong, Weien Chow, Wann Jia Loh*. Low-density lipoprotein cholesterol goal attainment and mortality in ischaemic heart disease after 2 years of lipid modifying treatment .Singapore Medical Journal, accepted Oct 2024, to be published in Jan 2025
  • Wann Jia Loh and Gerald F Watts. Cardiometabolic risk factors in women: what's sauce for the goose is not sauce for the gander. Current Opinion in Endocrinology & Diabetes and Obesity, August 28 2024. Curr Opin Endocrinol Diabetes Obes. 2024 Aug 28. PMID: 39221620
  • Ming Yi Koh, Keith Toh, Enver Loh, YNT, KCJ, QXT, VKS, LLLY, CHS, Wann Jia Loh* and Benjamin Tan*. Association of elevated lipoprotein(a) levels with ischaemic stroke in young patients - a systematic review and meta-analysis" in Journal of Stroke and Cerebrovascular Diseases. 31 Aug 2024 Meta-Analysis J Stroke Cerebrovasc Dis 2024 Nov;33(11):107960. doi: 10.1016/j.jstrokecerebrovasdis.2024.107960
  • Wann Jia Loh, Dick Chan, Jing Pang, Amanda Hooper, Damon Bell, Gerald F Watts. Opportunistic Detection of Phytosterolaemia during Genetic Testing for FH: Case Series and Contextual Review. Published in J Clin Endocrinol Metab. 2024 Jun 25:dgae437. doi: 10.1210/clinem/dgae437 July 2024 PMID: 38915260 DOI: 10.1210/clinem/dgae437
  • Clara Tan, Wann Jia Loh, Tavintharan Subramaniam, CF Sum, Su Chi Lim. An Asian Monogenic Diabetes Registry – prevalence, long-term renal trajectory and development of a diagnostic algorithm for selection of candidates for genetic testing. Singapore Medical Journal, accepted 23.5.2024
  • Wann Jia Loh*, Heng Samuel Soh, hon Hnin Tun, Pei ting tan, Chin Shern Lau , Subramaniam Tavintharan, Gerald F Watts and Tar Choon Aw. Elevated remnant cholesterol and non-HDL concentration in clinical practice: a cross-sectional study in Southeast Asians. Frontiers in Cardiovascular Science and highlighted in the "Women in Lipids in cardiovascular disease",  22 Jan 2024.
  • Wann Jia Loh*,  Jadegoud Yaligar, Amanda J Hooper, Suresh Anand Sadananthan, Yeshe Kway, Su Chi Lim, Gerald F Watts, Sambasivam Sendhil Velan, Melvin Khee Shing Leow, and Joan Khoo. Clinical and Imaging Features of Women with Polygenic Partial Lipodystrophy: A Case Series : accepted to Nutrition and Diabetes (impact factor 6.1, 19Jan2024, *top 20 Thomson )
  • Gayri Gupta, Ada Teo, Du Soon Swee, Lih Ming Loh, Matthew Chuah, Wann Jia Loh, Seyed Ehsan Saffari, Xuan Han koh, Peng Chin Kek, Troy H Puar. Prolonged Hypokalemia and Delayed Diagnosis of Primary Aldosteronism: Clinical Course and Risk Factors", has been accepted for publication in The Journal of Clinical Endocrinology & Metabolism, accepted 19 dec 2023. PMID 83134306
  • Wann Jia Loh*, Jing Pang, Anindita Chakraborty, Natalie C Ward, Dick C Chan, Amanda J Hooper, Damon A Bell, John R Burnett, Andrew C Martin,and Gerald F Watts. Cascade testing of children and Adolescents for elevated Lp(a) in Pedigrees with Familial Hypercholesterolaemia. Journal Clinical Lipidology (nov 2023)
  • Fionn Chua, Audrey Lam, YiHui Mak, Zhong Hui Lee, Lily Mae Dacay, Jie Lin Yew, Troy Puar, Joan Khoo, Weien Chow, Vern Hsen Tan, Khim Leng Tong, Boon Wah Liew, Colin Yeo and Wann Jia Loh*. Undiagnosed Cardiovascular Risk Factors including Elevated Lipoprotein(a) in Patients with Ischaemic Heart Disease. Frontiers in Epidemiology-Cardiovascular Epidemiology, July 2023. Also added to collection "Women In Cardiovascular Epidemiology".
  • Gerald Sng, You Liang Koo, Khung Keong Yeo, Wann Jia Loh, Tar Choon Aw, Joan Joo Ching Khoo, Lynette Mei Yi Lee, Gilbert Choon Seng Tan, Hong Chang Tan, Yong Mong Bee. Comparison of existing methods of low-density lipoprotein cholesterol estimation in patients with type 2 diabetes mellitus. Annals Academic Medicine Singapore.June .2023
  • Proton-pump inhibitor use amongst patients with severe hypomagnesemia Frontier Endocrinology Jan 2023 Sherry Seah,  K Tan, Kevin Teh, Wann Jia Loh, PT Tan, LC Goh, R Malakar, TC Aw, C S Lau, T Dhalliwal, SL Kui, J W Ka, J Khoo, TL Tay, ETan, V Au, SB Soh, MF Zhang, T F King, LyGani, Troy H Puar PMID: 36794273 
  • Wann Jia Loh* and Gerald F Watts. The Management of Hypercholesterolemia in Patients with Neuromuscular Disorder. Current Atherosclerosis Reports. Dec 2022 PMID: 36609642 DOI: 10.1007/s11883-022-01077
  • Wann Jia Loh* and Gerald F Watts . Xenosterolemia in clinical practice: what is in a name? Current Opinion in Endocrinology & Diabetes and Obesity. PMID: 36597814   DOI: 10.1097/MED.0000000000000795 December 2022
  • Wann Jia Loh* and Gerald F Watts . Detection strategies for elevated lipoprotein(a): will implementation let the genie out of the bottle? Current Opinion in Endocrinology & Diabetes and Obesity ():10.1097/MED.0000000000000789, December 06, 2022. | DOI: 10.1097/MED.0000000000000789 PMID: 36468313 December 2022
  • Chong Boon Teo , Ming Yi Gan , Ryan Yong Kiat Tay , Wann Jia Loh , Ne-Hooi Will Loh Association of preoperative hyponatremia with surgical outcomes: a systematic review and meta-analysis of 32 observational studies. JCEM   PMID: 36472931 DOI: 10.1210/clinem/dgac685 December 2022
  • Paul Nestel, Wann Jia Loh, Natalie C Ward, Gerald F New Horizons: Revival of Lipoprotein(a) as a Risk Factor for Cardiovascular Disease. JCEM. PMID: 36108076 Nov 2022
  • Wann Jia Loh*, R Bakthavachalam, T Subramaniam, S Pek, F Chua, L Lee and Gerald Watts Chylomicronemia through a burr hole: A case report. Frontiers in Cardiovascular Medicine. October 2022 PMID 36312279
  • Natalie Ward, Wann Jia Loh, Gerald F Watts Endothelial dysfunction in type 2 diabetes, with an update on new interventions.   Book Chapter in Lipoprotein and Diabetes-Edition II ( published 2023)          
  • CB Teo, PY Tan, Yong Ryan, Joan Khoo, Gerald Watts, Wann Jia Loh*. Association Between Vitamin D   Supplementation and Statin-Associated Muscle Symptoms: A Systematic Review, 29 June 2022 Journal: High Blood Pressure and Cardiovascular Prevention, 29,337-351(2022)                                           
  • Puar TH, Cheong CK, Foo RSY, Saffari SE, Tu TM, Chee MR, Zhang M, Ng KS, Wong KM, Wong A, Ng FC, Aw TC, Khoo J, Gani L, King T, Loh Wann Jia, Soh SB, Au V, Tay TL, Tan E, Mae L, Yew J, Tan YK, Tong KL, Lee S, Chai. Treatment of Primary Aldosteronism and Reversal of Renin Suppression Improves Left Ventricular Systolic Function. Frontier Endocrinology (Lausanne). 2022 Jun 30;13:916744. doi: 10.3389/fendo.2022.916744. 2022.PMID: 35846272
  • Wann Jia Loh*, Dick Chan, Pedro Mata and Gerald Familial hypercholesterolemia and elevated lipoprotein(a): cascade testing and other implications for contextual models of care ,published 27 Apr 2022. Frontiers in Genetics, Research topic: Genetics of Familial Hypercholesteroemia: New Insight-Volume II
  • Lynette Lee, Sarah Tan and Wann Jia Loh .High urinary sodium concentrations in severe SIADH: case reports of 2 patients and literature review.  Frontiers in Medicine, section Nephrologyàaccepted 16 April 2022
  • Chong Boon Teo, Pek Yan Tan, Shan Xian Lee, Joan Khoo, Jun Guan Tan, Su Fen Ang, Sze Hwa Tan, Tunn Lin Tay, Eberta Tan, Su Chi Lim, Bernhard Otto Boehm, Wann Jia Loh*.  Insulin Allergy to Detemir Followed by Rapid Onset of Diabetic Ketoacidosis: A Case Report and Literature Review .Frontiers in Endocrinology, section Clinical Diabetes, 08 March 2022 https://doi.org/10.3389/fendo.2022.844040
  • Wann Jia Loh and Gerald F Watts: Inherited Hypercholesterolemias . Chapter in Endocrinology and Metabolism Clinics of North America -in Press July 2022
  • WJ Loh, Chang X, Aw TC, SK Phua, A F Low, Mark C, G Watts, CK Heng Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population. Atherosclerosis - Nov 2021 PMID: 34887076https://doi.org/10.1016/j.atherosclerosis.2021.11.018
  • Clara Tan, SF Ang, BX Goh, Wann Jia Loh CF Sum, Su Chi Lim. MODY5 Hepatocyte Nuclear Factor 1 (HNF1β)-associated nephropathy: experience from a regional monogenic diabetes referral center in Singapore . PMID: 35038894 DOI: 10.1177/23247096211065626 Journal of Investigative Medicine High Impact Case Reports -accepted Dec 2021
  • Fengjie Tang, LM Loh, Roger S. Foo, 3,4 Wann J. Loh. Troy Puar By Tolerability and Efficacy of Long Term Medical Therapy in Primary Aldosteronism .Journal of the Endocrine Society, Nov 2021  https://doi.org/10.1210/jendso/bvab144
  • YK Tan, Wann Jia Loh, Troy Puar Improvement in Quality of Life and Psychological Symptoms After Treatment for Primary Aldosteronism: Asian Cohort Study. Endocrine Connections July 2021, PMID: 34223820
  • Wann Jia Loh, Lily Mae Dacay, Clara Si Hua Tan, Su Fen Ang, Fabian Yap, Su Chi Lim, Joan Khoo. Glucokinase activating mutation causing hypoglycaemia diagnosed late in adult who fasts for Ramadhan Endocrinology, Diabetes Metabolism Case Reports June 2021 PMID 34184638
  • Yvonne Chan, LM Loh, Roger Foo, Wann Jia Loh, Peng Chin Kek, Troy Puar Re-evaluating absent clinical success after adrenalectomy in unilateral primary aldosteronism .Surgery, PMID 34183182 25 June 2021
  • Louis Tee, Sharifah Wann Jia Loh,Barbara Rosario. COVID19 and undiagnosed pre-diabetes or diabetes mellitus among international migrant workers in Singapore. Frontiers in Public Health ,PMID33262970 Nov 2020
  • Puar TH, Loh LM, Loh Wann Jia, Dawn Lim, Zhang MF…. Roger Foo.Outcomes in unilateral primary  aldosteronism after surgical or medical therapy. Clinical Endocrinology Oct 2020, PMID 33058182
  • Chua TH,and Loh Wann Jia. Osmotic Demyelination syndrome in a patient with Noonan syndrome and anterior hypopituitarism.Endocrinology, Diabetes, Metabolism Case Report 2020 Aug PMID 32820141
  • Kangqi Ng, Beng Hoong Poon, Troy Hai Kiat Puar, Jessica Li Shan Quah, Wann Jia Loh, Yu Jun Wong, Thean Yen Tan, Jagadesan Raghuram. COVID-19 and the Risk to Health Care Workers: A Case Report Annals of Internal Medicine March 2020 PMC7081171
  • Wann Jia Loh, Louise Hughes, David Thai Chong Chua, Linsey GaniA Case Report of Mixed Osteomalacia and Low Bone Density from Vitamin D Deficiency as a Cause of Bilateral Tibial Stress Fractures in a Young Male Military Recruit from Singapore. Case Report of Endocrinology Jan 2020
  • Puar TH, Loh WJ, Lim DS, Loh LM, Zhang M, Foo RS, Lee L, Swee DS, Khoo J, Tay D, Kam JW, Dekkers T, Velema M, Deinum J, Kek PC. Dec 2019, PMID 31851033 Aldosterone--potassium ratio predicts primary aldosteronism subtype. Journal of Hypertension 2019
  • Wann Jia Loh, John Stevenson, Ian Godsland Independent relationships between bone mineral density, regional body fat and insulin sensitivity in white males. Date 2019 Jul;91(1):63-71. doi: 10.1111/cen.13989. Epub 2019 Apr 24. PMID30973644 Clinical Endocrinology
  •  Wann Jia Loh, DST Lim, LM Loh, PC Kek Factors Associated with Resolution of Hypertension afterAdrenalectomy in Patients with Primary Aldosteronism. Date: Sep 2018 ;33(3):355. 363.doi:10.3803/EnM.2018.33.3.355. Epub 2018 Aug 14. PMID:3011286 Endocrinology and Metabolism(Seoul)
  • Loh Wann Jia, Johnston DG, Oliver N, Godsland IF. Skinfold thickness measurements and mortality in white males during 27.7years of follow-up Date : 20 feb 2018 doi:10.1038/s41366-018-0034-0 PMID: doi: 10.1038/s41366-018-0034-4. International Journal of Obesity (2018) .PMID29491491
  • Wei Lin Tay, Wann Jia Loh, LAL Lee, Chiaw Ling Chng By Persistent hyperthyroidism and de novo Graves' ophthalmopathy after total thyroidectomy. Date Oct 13 2017 pii: 17-0109. doi: 10.1530/EDM-17-0109 Endocrinology, Diabetes and Metabolism Case Reports PMID: 29062485
  • Wei Lin Tay, Wann Jia LOH, Peng Chin Kek. A case of pembrolizumab-induced type 1 diabetes mellitus presenting with severe diabetic ketoacidosis.      Date: 31 July 2017           Journal of clinical and Translational Endocrinology: case reports 6(2017) 9-10
  • Loh Wann Jia, Yu Yue, Loo Chian Min, Low Su Ying .By Factors associated with Mortality among Patients with Active Pulmonary Tuberculosis requiring intensive care ,Date: June 2016 Singapore Medical Journal    PMID:27653545 DOI:10.11622/smedj.2016160
  • Loh Wann Jia, Chan Weng Hoong, Tham Kwang Wei .Torsion of the Wandering Spleen and Pancreatic Tail. Precipitating Diabetic Ketoacidosis in a Patient with Prader Willi Syndrome ,Date: 16 February 2016.Journal of the ASEAN Federation of Endocrine Societies (JAFES)
  • Wee Ming Peh, Wann Jia LOH, Ghee Chee Phua, Chian Min Loo Eliminating guidewire retention during ultrasound guided central venous catheter insertion via an educational program, a modified CVC set, and a drape with reminder stickers, Date: 12 February 2016.Journal:BMJ Quality Improvement Report 2016 PMID:27493743  doi:10.1136/bmjquality.u209550.w3941
  • Loh Wann Jia, Kesavan Sittampalam, Tan Suan Cheng, Manju Chandran.'Symptomatic Empty Sella Syndrome– An unusual manifestation of Erdheim-Chester Disease. Endocrinology, Diabetes and Metabolism Case Reports Date:2015.PMID:25810917, doi: 10.1530/EDM-14-0122
  •  LOH Wann Jia, North BV, Johnston DG, Godsland IF. By Insulin resistance-related biomarker clustering and subclinical inflammation as predictors of cancer mortality during 21.5 years of follow-up. Journal: Cancer Causes Control Date: May 2010PMID:20072808, doi: 10.1007/s10552-009-9499-4


Research Trials