Common side effects include:

• Nausea
• May occur when you start to take this medication but will become less as you continue to take the medication. Take the medication after food to reduce nausea.
• Constipation
• Drink more water if your doctor did not tell you to restrict fluid intake and take more food that contains fibre.
• Dry mouth
• Headache
• Dizziness
• Avoid driving or engaging in activities that require concentration. Get up slowly from a sitting or lying down position.
• Drowsiness
• Avoid driving or engaging in activities that require concentration.

Very rarely, a condition known as serotonin syndrome may happen when tramadol is taken with certain medications such as those used in treating depression. This can cause serious health problems that may sometimes be life-threatening. Consult a doctor immediately if you feel unusually unsettled, or experience hallucinations, muscle stiffness, very bad diarrhea or headaches.

The symptoms of a drug allergy include one or more of the following:

• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

​Inform your healthcare professional if:

• You are allergic to this medication, any of the other ingredients of this medication or opioid pain medication such as Codeine, Morphine or Fentanyl.
• You have a history of   
• Kidney condition
• Liver condition
• Seizures (fits)
• Heart condition
• Lung condition
• You are pregnant, planning to become pregnant, or breastfeeding.   
• You are taking any other medications, including supplements, traditional medications and herbal remedies

• ​Avoid taking alcohol with tramadol as it may cause excessive drowsiness. If you are taking Ultracet, which is a combination of tramadol and paracetamol, do not take more paracetamol-containing products.
• Avoid taking tramadol with other medications that may cause drowsiness e.g. sleeping pills without checking with your doctor first.