Common side effects include:

• Nausea and vomiting
• Take small, frequent meals throughout the day.
• Decreased appetite
• Diarrhea or constipation
• To manage diarrhoea:
• Drink plenty of clear fluids to replace those lost (2 litres everyday).
• Avoid oily or spicy food and milk or dairy products.
• To manage constipation:
• Drink more water or clear fluids (if you do not have a limit on the amount that you can take each day).
• Add more fibre to your diet by eating more fruits and vegetables.
• Rash
• Avoid taking hot showers.
• Hair loss
• Use a gentle shampoo to wash your hair.
• Feeling tired and lack of energy
• Do not drive or operate machinery when you feel tired.
• Headache
• Decreased white blood cells
• This may put you at higher risk of infections.
• To reduce your risk of infection:
• Avoid crowds and people who are sick. Wear a face mask when you are going out.
• Wash your hands after using the toilet and before handling food.
• Eat food that is fresh and completely cooked, and avoid raw or half-cooked food.

If any of these side effects are severe, see your healthcare professional immediately.

Rare but serious side effects include:

• Signs of infection - fever of 38°C and above, chills, cough, sore throat, pain or burning feeling on passing urine
• Unusual bleeding, bruising, black sticky stools or blood in urine
• Cough with chest pain or breathing difficulty
• Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
• Fast or irregular heartbeat, chest discomfort or if you feel faint, light-headed, or dizzy

The symptoms of a drug allergy including one or more of the following:

• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Inform your healthcare professional if:

• You are allergic to this medication
• You or your partner become pregnant or is planning for pregnancy
• You should use effective birth control during and for 3 weeks after stopping Ribociclib.
• You are breastfeeding
• Do not breastfeed during treatment.
• You have any other medical conditions such as heart disease

• ​Avoid taking grapefruit and pomegranate when you are taking this medication as these may interact with your medication and increase the risk of side effects.
• Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies.

• Take Ribociclib once a day for 3 weeks, followed by 1 week of rest, in a 4-week cycle.
• You can take it with or without food.
• Do not break, chew or crush the tablet. Swallow the tablet whole.
• Inform your doctor or pharmacist if you have difficulty swallowing.

If you forget to take a dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time to make up for the missed dose.

• Keep away from children
• Keep in a cool, dry place, away from direct sunlight

Pack Ribociclib into a bag and bring it back to the pharmacy where you received it from.

​You may refer to the following website if you need more information: https://www.macmillan.org.uk/