Skip Ribbon Commands
Skip to main content

Intranasal Midazolam Administration

Drug Class: Commonly Known As: Category:
Benzodiazepines Adult, Children

Intranasal Midazolam Administration - What is it for

Intranasal Midazolam Administration - Side Effects, Precautions, and Contraindications

What side effects can Intranasal Midazolam Administration cause?

Before taking Intranasal Midazolam Administration , what precautions must I follow?

What food or medicine must I avoid when I take Intranasal Midazolam Administration ?

Intranasal Midazolam Administration - Dosage and How to Use

How should Intranasal Midazolam Administration be used?

Note: Ensure nose is not blocked prior to administration of midazolam

​Step 1:


  • Remove blunt needle cover
  • (Do not dispose blunt needle cover)

  • Assemble the blunt needle and the syringe as shown in this picture

Step 4:


  • Place the assembled needle and syringe into the ampoule as shown
  • Withdraw the prescribed volume of solution
  • Hold the syringe upright with nozzle facing up against the light to check that the solution is clear
  • Expel trapped air if present. Withdraw midazolam again if volume falls below prescribed
  • Cap the blunt needle once the required volume has been withdrawn
  • Remove the capped needle

Step 2:


  • Gently swirl the Midazolam ampoule (15mg/3mL) until all the solution is at the bottom as shown in the picture on the right
  • The solution should be clear; do not use if cloudy.

Step 5:


  • Assemble the atomizer to the syringe as shown

Step 3:


  • Hold the bottom part of the ampoule between the thumb and first finger of one hand.
  • Ensure that the spot on the ampoule is facing away from you
  • If possible, cover the top of the ampoule with a tissue or towel before holding the top between the thumb and first finger of your other hand.
  • Snap the top of the ampoule off by pushing away from the side with the spot (in the direction of the arrow).

Step 6:


  • Lie the child on a flat surface
  • Place the assembled atomizer and the syringe firmly on the nostril
  • Press the plunger of the syringe quickly to administer about half of the volume as atomised spray into a nostril
  • Move the device over to the opposite nostril and administer the remaining medication into that nostril


​ ​Intranasal midazolam dosing chart

Volume of midazolam = dose volume + 0.1 ml (atomizer dead space).

​ ​ ​

Patient age in months

WeightDose* Volume (5mg/ml)
​1 month to 5 months old​6 kg​1.2 mg0.3 ml​
​6 month old and older ​6.1 to 8 kg ​1.6 mg0.4 ml​
8.1 to 10 kg​2 mg​0.5 ml​
​10.1 to 14 kg3 mg​​0.7 ml
​14.1 to 20 kg4.2 mg​​0.9 ml
​20.1 to 28 kg6 mg​​1.3 ml
​28.1 to 35 kg8.4 mg​​1.8 ml
Teenager or adult ​35.1 kg or more ​10 mg​2 ml

* Volume is based on the calculated dose plus 0.10 ml dead space in the device

For children 1 month to 5months old, intranasal midazolam is dosed at 0.2mg/kg/dose.

For children of 6 month old to adults, intranasal midazolam is dosed at 0.2 – 0.3mg/kg/dose. Max of 10mg/dose.

What should I do if I miss a dose?

What should I do if I overdose?

  • Updated on 8/16/2017 12:00:00 AM
  • Article contributed by Pharmacy Department KK Women's and Children's Hospital
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

Find Your Medicines