Pain relief for stiff and swollen joints is usually possible with non-steroidal anti-inflammatory drugs. Areas of dry and irritated skin can be helped by a regular moisturiser. Antihistamines may help with intense itching of the skin.

For Raynaud’s phenomenon, it is important to keep warm and to stop smoking. 

Medication to improve blood may be prescribed, while antibiotics can protect skin ulcers from getting infected. Proper wound care to promote ulcer healing can help to slow down the progression in scleroderma.

For oesophageal involvement, H2 blockers, proton pump inhibitors or prokinetics may be prescribed. Simple measures such as avoiding acidic foods, eating smaller and more frequent meals, elevating the head of the bed and avoiding lying down for at least 3 hours after a meal can help to decrease symptoms of acid reflux.

When a patient is diagnosed with diffuse scleroderma, medication may be prescribed to decrease the activity of the immune system. When internal organs are affected by the condition, other specific treatments may be needed.