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Asst Prof Yeo Joo Guan

Asst Prof Yeo Joo Guan

MBBS, MMed (Paed), MRCPCH (UK), PhD

Senior Consultant

KK Women's and Children's Hospital

Specialty: Paediatric Medicine

Clinical Appointments

  • Senior Consultant KK Women's and Children's HospitalKK Women's and Children's Hospital


Dr Yeo Joo Guan is a Senior Consultant in Paediatric Medicine in KK Women’s and Children’s Hospital. He earned his M.B., B.S. and Masters of Medicine (Paediatric Medicine) from the National University of Singapore (NUS). During his advanced speciality training, he obtained his Ph.D. from the Department of Microbiology, Immunology programme, NUS, on the role of serine protease C1s in lupus pathogenesis supported by the Ministry of Health's Healthcare Research Scholarship in 2014.

Following the completion of his advanced speciality training in 2015, he was mentored by Professor Salvatore Albani (SingHealth Translational Immunology and Inflammation Centre) with the support of Academic Medicine Research Institute's Khoo Clinical Scholar Program for 1 year, working on the holistic, multi-dimensional interrogation of the immunome of childhood onset Systemic Lupus Erythematosus with the dual translational goals of identifying predictors of clinical fate and novel therapeutic targets for manipulation. The pilot results from this study has resulted in the successful application for the National Medical Research Council's Transition Award during the November 2016 grants call with the project entitled: "Interrogation of Childhood Onset Systemic Lupus Erythematosus Immunome for the Elucidation of Disease."


  • PhD (Spore) 2014
  • MMED Paediatrics (Spore) 2006
  • MRCPCh (United Kingdom) 2006
  • MBBS National University of Singapore 2000

Professional Appointments and Committee Memberships

  • Senior Consultant, Division of Medicine, KK Women’s and Children’s Hospital 2021 – Present
  • Consultant, Division of Medicine, KK Women’s and Children’s Hospital 2017 – 2021
  • Member, Hospital Research Committee, KK Women’s and Children’s Hospital 2021 – Present
  • Deputy Vice-Chair (Research), SingHealth Duke-NUS Paediatrics Academic Clinical Programme
  • Assistant Professor, Duke-NUS Medical School
  • Clinician Scientist, Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre


  • Khoo Clinical Scholar Programme, 2016
  • SingHealth Best Registrar Award, 2013
  • ExxonMobil-NUS Research Fellowship 2013 for Clinicians, 2013
  • Dean’s Award for Teaching Excellence (Academic Year 2009/2010), 2010
  • NRF-MOH Healthcare (PhD) scholarship, 2009
  • Master of Medicine (Paediatric Medicine) (Singapore) Nestle Silver Medal, 2007
  • SingHealth Junior Doctor Award, 2007

Research Interests

  • Cellular and molecular immunology.
  • Role of B regulatory cells in childhood onset Systemic Lupus Erythematosus and its translational potential as a form of cell therapy.
  • Development of a healthy paediatric immune cell atlas, using different multi-dimensional platforms such as mass cytometry and single cell RNA sequencing, for the comprehensive description of the developing immunome in a clinically and functionally relevant manner.
  • Applying the multi-dimensional approach to different paediatric diseases with an immunological component through the integration of different high throughput ‘omics’ platforms for the elucidation of the underlying disease mechanism.


  • Extended Polydimensional Immunome Characterization (EPIC) as a Web-based Reference and Discovery Tool for Cytometry Data. Yeo JG, Wasser M, Kumar P, Pan L, Poh SL, Ally F, Arkachaisri T, Lim AJM, Leong JY, Lai L, Yeo KT, Lee ESC, Chua CJH, Larbi A, Nyunt MSZ, Ng TP, Chiesa S, Gattorno M, Martini A, Paleja BS, Dutertre CA, Chen J, Nay Yaung K, Tang SP, Ng SK, Yung CF, Tan AYJ, Lee SY, Ginhoux F, Albani S. Nat Biotechnol. 2020 Jun; 38(6): 757.
  • Endothelial and Inflammation Biomarker Profiles at Diagnosis Reflecting Clinical Heterogeneity and Serving as a Prognostic Tool for Treatment Response in Two Independent Cohorts of Patients With Juvenile Dermatomyositis. Wienke J, Pachman LM, Morgan GA, Yeo JG, Amoruso MC, Hans V, Kamphuis SSM, Hoppenreijs EPAH, Armbrust W, van den Berg JM, Hissink Muller PCE, Gelderman KA, Arkachaisri T, van Wijk F, van Royen-Kerkhof A. Arthritis Rheumatol. 2020 Jul;72(7):1214-1226. doi: 10.1002/art.41236.
  • Risk of malignancies in patients with spondyloarthritis treated with biologics compared with those treated with non-biologics: a systematic review and meta-analysis. Kwan YH, Lim KK, Fong W, Goh H, Ng L, Haaland B, Phang JK, Low LL, Yeo JG, Huang F, Leung YY, Thumboo J, Østbye T. Ther Adv Musculoskelet Dis. 2020 May 28;12:1759720X20925696. doi: 10.1177/1759720X20925696. PMID: 33149771.
  • Insights into the immuno-pathogenesis of acute respiratory distress syndrome. Wong JJM, Leong JY, Lee JH, Albani S, Yeo JG. Annals of translational medicine. 2019;7(19):504.
  • Mortality in Pediatric Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Wong JJ, Jit M, Sultana R, Mok YH, Yeo JG, Koh J, Loh TF, Lee JH. Journal of intensive care medicine. 2019;34(7):563-71. 
  • Galectin-9 and CXCL10 as Biomarkers for Disease Activity in Juvenile Dermatomyositis: A Longitudinal Cohort Study and Multicohort Validation. Wienke J, Bellutti Enders F, Lim J, Mertens JS, van den Hoogen LL, Wijngaarde CA, Yeo JG, Meyer A, Otten HG, Fritsch-Stork RDE, Kamphuis SSM, Hoppenreijs E, Armbrust W, van den Berg JM, Hissink Muller PCE, Tekstra J, Hoogendijk JE, Deakin CT, de Jager W, van Roon JAG, van der Pol WL, Nistala K, Pilkington C, de Visser M, Arkachaisri T, Radstake T, van der Kooi AJ, Nierkens S, Wedderburn LR, van Royen-Kerkhof A, van Wijk F. Arthritis & rheumatology (Hoboken, NJ). 2019;71(8):1377-90.
  • Immunomics in Pediatric Rheumatic Diseases. Tay SH, Yaung KN, Leong JY, Yeo JG, Arkachaisri T, Albani S. Frontiers in medicine. 2019;6:111.
  • Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFalpha withdrawal. Leong JY, Chen P, Yeo JG, Ally F, Chua C, Nur Hazirah S, Poh SL, Pan L, Lai L, Lee ESC, Bathi LDT, Arkachaisri T, Lovell D, Albani S. Annals of the rheumatic diseases. 2019;78(12):1712-21.
  • Pro-inflammatory, IL-17 pathways dominate the architecture of the immunome in pediatric refractory epilepsy. Kumar P, Shih DCW, Lim A, Paleja B, Ling S, Li Yun L, Li Poh S, Ngoh A, Arkachaisri T, Yeo JG, Albani S. JCI insight. 2019;5.
  • Recent advances in our understanding of the pathogenesis of juvenile idiopathic arthritis and their potential clinical implications. Leong JY, Yeo JG, Albani S, Arkachaisri T. Expert review of clinical immunology. 2018;14(11):933-44.
  • The Singapore Paediatric Triage Scale Validation Study. Ganapathy S, Yeo JG, Thia XHM, Hei GMA, Tham LP. Singapore Med J. 2017 Oct 6. (Epub ahead of time)
  • Precision medicine in pediatric rheumatology. Yeo JG, Ng CT, Albani S. Curr Opin Rheumatol. 2017 Sep; 29(5): 500-505.
  • Singlet gating in mass cytometry. Lai L, Yeo JG, Albani S. Cytometry. Part A: the journal of the International Society for Analytical Cytology 2017; 91(2): 170-172. 14. Mortality in Pediatric Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Wong JJ, Jit M, Sultana R, Mok YH, Yeo JG, Koh JWJC, Loh TF, Lee JH. J Intensive Care Med. 2017 Jan 1. (Epub ahead of time)
  • The modified respiratory index score (RIS) guides resource allocation in acute bronchiolitis. Chong SL, Teoh OH, Nadkarni N, Yeo JG, Lwin Z, Ong YG, Lee JH. Pediatr Pulmonol. 2017 Jul; 52(7): 954-961.
  • Complement the cell death. Yeo JG, Leong J, Lu J. Cell Death Dis. 2016 Nov 10; 7(11): e2465.
  • Proteolytic inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during apoptosis. Yeo JG, Leong J, Arkachaisri T, Cai Y, Teo BH, Tan JH, Das L, Lu J. Cell Death Discov. 2016 Sep 12; 2: 16069.
  • C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins. Cai Y, Teo BH, Yeo JG, Lu J. J Biol Chem. 2015 Sep 11; 290(37): 22570-80.
  • Epidemiology of pediatric acute respiratory distress syndrome in Singapore: risk factors and predictive respiratory indices for mortality. Wong JJ, Loh TF, Testoni D, Yeo JG, Mok YH, Lee JH. Front Pediatr. 2014 Jul 25; 2: 78.
  • C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulation. Teh BK, Yeo JG, Chern LM, Lu J. Mol Immunol. 2011 May; 48(9-10): 1128-38.
  • Pertussis--an under-diagnosed disease with high morbidity in Singapore children. Goh A, Chong CY, Tee N, Loo LH, Yeo JG, Chan YH. Vaccine. 2011 Mar 16; 29(13): 2503-7.

Research Trials