You are invited to attend this seminar hosted by the Institute of Molecular and Cell Biology:
Date: Wednesday, 24 January 2024
Time: 11.00AM – 12.00PM
Venue: IMCB Seminar Room 03-46, Level 3 Proteos, Biopolis, Singapore 138673 (Physical)
Speaker: Dr. Gene-Wei Li, MIT
Host: Prof. Han Weiping, IMCB
Protein ‘Mixology’: Requirements and Mechanisms of Precise Protein Synthesis
Abstract
Cells possess specific compositions of proteins that define their physiology. I will discuss our research that is focused on elucidating the physiological requirements and mechanistic basis of the precise rates of protein production. Using bacterial model systems, we develop quantitative approaches to measure, manipulate, and model how co-transcribed genes produce distinct proportions of proteins, as well as how imbalanced production affects cell fitness. Our ultimate goal is to establish predictive frameworks to derive quantitative protein expression levels and their effects on bacterial growth physiology from operon sequences.
Biography
Gene-Wei (Gene) Li completed his PhD in Physics at Harvard University in 2010 and postdoctoral training at University of California, San Francisco in 2014. He joined the faculty at MIT in 2015. He is a recipient of the NSF Career Award, Pew Biomedical Scholar, Searle Scholar, Sloan Research Fellowship, the Smith Odyssey Award, and the MIT Committed to Caring Mentorship Award. The Li lab uses bacteria as a model to decipher the physical and chemical principles behind the precise control of gene expression that cells have mastered through evolution.
ALL ARE WELCOME (No registration required)
