You are invited to attend this seminar hosted by the Institute of Molecular and Cell Biology:
Date: Wednesday, 22 March 2023
Time: 11.00AM – 12.00PM
Host: Prof Jonathan Loh
Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend Lifespan
Abstract
Why biological age is a major risk factor for many of the most important human diseases remains poorly understood. We know that, as organisms age, stem cell pools are exhausted while senescent cells progressively accumulate. I will discuss how induction of pluripotency via expression of Yamanaka factors and clearance of senescent cells can ameliorate aspects of cellular and physiological aging, and how combination therapies work to extend lifespan and healthspan.
Biography
Dr. Nicholas Tolwinski is an Associate Professor at Yale-NUS. He received a PhD from Princeton University in Molecular Biology in 2004. After completing his PhD, he became the first Frank A. Howard Scholar in the Developmental Biology at Memorial Sloan-Kettering Cancer Center. His laboratory specializes in analyzing the early embryonic development of Drosophila. His research focuses on modeling systems of signal transduction organizing groups of cells into tissues, and what goes wrong with these processes leading to cancers. The laboratory’s primary focus is on Wnt signaling in development and aging.
ALL ARE WELCOME (No registration required)
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