NNRIS is a joint institute by the National Neuroscience Institute (NNI) and Duke-NUS Medical School. NNRIS synergises expertise from both organisations to develop research programmes, integrate resources and new research facilities for experiments. This year, we celebrate the 10th anniversary of NNRIS by organising this symposium which is the largest gathering of local neuroscientists from both clinical and basic science.This symposium includes 2 Plenary sessions and 6 Parallel sessions of the following 6 themes: Parkinson's Disease, Dementia, Stroke and Cerebral Vascular Diseases, Neuroinflammation, Stem Cells and Neurodevelopment, and Emerging Technologies & Novel Therapies.