The blood vessels of the heart are called coronary arteries.
Sometimes, fatty material or plaque from cholesterol
build-up may narrow the blood vessels of the heart.
This plaque reduces the amount of oxygen supply to the
heart, causing chest discomfort or spasmodic pain (angina).
Normal coronary arteries are widely patent and have
large, smooth and regular lumen. However, in patients
with coronary artery diseases the inside of one or more
of the arteries is normal or blocked by a lot of built-up
of a porridge-like material called atheroma within the
wall of the artery. A major component of atheroma is
cholesterol and calcium. If the build-up of this fat
and cholesterol-atheroma (plaque) is extensive enough,
oxygen supply to the heart is reduced causing chest
discomfort, pressure, or spasmodic pain (angina). Other
symptoms of CAD include irregular heartbeat, breathlessness
and tireness.
Prolonged chest pain occurs when the
narrowed arteries are blocked off suddenly and completely.
This is due to the lack of oxygen in the heart cells
resulting in their death - a condition called myocardial
infarction or more commonly, heart attack.
Medical research has identified some
risk factors for CAD. People with the following risk
factors have a higher chance of getting CAD:
- Smoking
- High blood pressure
- Overweight
- High levels of fatty substance,
such as cholesterol, in the blood
- Lack of exercise
- Stress
- Diabetes
- Family history of heart
disease
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